Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 436, Issue 1-2, Pages 379-386Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2012.06.039
Keywords
Galactosylated chitosan; Nanoparticles; Oridonin; Tumor targeting
Categories
Funding
- National Basic Research Programme of China (973 Programme) [2009CB930300]
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In this study, oridonin-loaded nanoparticles coated with galactosylated chitosan (ORI-GC-NP) were prepared for tumor targeting and their characteristics were evaluated for the morphologies, particle size and zeta potential. Oridonin-loaded nanoparticles (ORI-NP) without galactosylated chitosan were prepared as a control. The entrapment efficiency of ORI-GC-NP and ORI-NP were 72.15% and 85.31%, respectively. The in vitro drug release behavior from nanoparticles displayed biphasic drug release pattern with initial burst release and consequently sustained release. Next, the pharmacokinetics and tissue distribution of ORI-GC-NP, ORI-NP and ORI solution were carried out. Pharmacokinetic analysis showed that ORI-GC-NP and ORI-NP could prolong the drug plasma levels compared with ORI solution. Meanwhile, the distribution of ORI-GC-NP to liver was higher than that of ORI-NP and free drug. In conclusion, ORI-GC-NP, as a promising intravenous drug delivery system for ORI, could be developed as an alternative to the conventional ORI preparations. (c) 2012 Elsevier B.V. All rights reserved.
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