Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 408, Issue 1-2, Pages 200-207Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2011.01.058
Keywords
Electrospinning; Drug-loaded nanofibers; Eudragit (R) L 100-55; Colon-targeted drug delivery
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Funding
- UK-CHINA Joint Laboratory for Therapeutic Textiles
- China Postdoctoral Science Foundation [200902195]
- Ministry of Education of P.R. China [B07024]
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Eudragit (R) L 100-55 nanofibers loaded with diclofenac sodium (DS) were successfully prepared using an electrospinning process, and characterized for structural and pharmacodynamic properties. The influence of solvent and drug content on fiber formation and quality was also investigated. Fiber formation was successful using a solvent mixture 5:1 (v/v) ethanol:DMAc. XRD and DSC analysis of fibers confirm electron microscopic evidence that DS is evenly distributed in the nanofibers in an amorphous state. FTIR analysis indicates hydrogen bonding occurs between the drug and the polymer, which accounts for the molecular integration of the two components. In vitro dissolution tests verified that all the drug-loaded Eudragit (R) L 100-55 nanofibers had pH-dependent drug release profiles, with limited, less than 3%, release at pH 1.0, but a sustained and complete release at pH 6.8. This profile of properties indicates drug-loaded Eudragit (R) L 100-55 nanofibers have the potential to be developed as oral colon-targeted drug delivery systems. (C) 2011 Elsevier B.V. All rights reserved.
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