Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 419, Issue 1-2, Pages 1-11Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2011.07.037
Keywords
Pharmaceutical cocrystal; Crystal engineering; Supramolecular synthon; Solution cocrystallisation; Grinding cocrystallisation; Cocrystal characterisation
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Pharmaceutical cocrystals are emerging as a new class of solid drugs with improved physicochemical properties, which has attracted increased interests from both industrial and academic researchers. In this paper a brief and systematic overview of pharmaceutical cocrystals is provided, with particular focus on cocrystal design strategies, formation methods, physicochemical property studies, characterisation techniques, and recent theoretical developments in cocrystal screening and mechanisms of cocrystal formations. Examples of pharmaceutical cocrystals are also summarised in this paper. (C) 2011 Elsevier B.V. All rights reserved.
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