Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 419, Issue 1-2, Pages 28-32Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2011.06.053
Keywords
Controlled release; AMS coatings; Chlorhexidine; Biofilm prevention; Staphylococcus aureus; Candida albicans
Categories
Funding
- K.U.Leuven interdisciplinary research project [IDO/06/013]
- Flemish Government (Methusalem)
- K.U.Leuven Industrial Research Fund
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Amorphous microporous silica (AMS) serving as a reservoir for controlled release of a bioactive agent was applied in the open porosity of a titanium coating on a Ti-6Al-4V metal substrate. The pores of the AMS emptied by calcination were loaded with chlorhexidine diacetate (CHX) via incipient wetness impregnation with CHX solution, followed by solvent evaporation. Using this CHX loaded AMS system on titanium substrate sustained release of CHX into physiological medium was obtained over a 10 day-period. CHX released from the AMS coating was demonstrated to be effective in killing planktonic cultures of the human pathogens Candida albicans and Staphylococcus epidermidis. This surface modification of titanium bodies with AMS controlled release functionality for a bioactive compound potentially can be applied on dental and orthopaedic implants to abate implant-associated microbial infection. (C) 2011 Elsevier B.V. All rights reserved.
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