Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 418, Issue 1, Pages 78-87Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2010.12.009
Keywords
Drug release mechanism; Mathematical models; Anomalous diffusion; Fractional calculus; Moving boundary problem; Exact and approximation solutions
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Funding
- National Natural Science Foundation of China [10825208, 10632010, 11002049]
- Jiangsu Planned Projects for Postdoctoral Research Funds [0902099C]
- Hohai University [2009427311]
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Mathematical models for the release of drug from both non-degradable and degradable slab matrices in which the initial drug loading is greater than the solubility are presented in this paper. Taking the anomalous diffusions in the drug release processes into account, the fractional calculus is introduced to model the related phenomena. To describe different kinds of anomalous diffusions, corresponding fractional diffusion equations are adopted. By employing the integral transform methods, similarity solution method and perturbation method, exact and approximation solutions to the models are obtained. (C) 2010 Elsevier B.V. All rights reserved.
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