Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 417, Issue 1-2, Pages 17-31Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2011.01.031
Keywords
Raman spectroscopy; Phonon Raman spectrum; Vibrational density of states; Polymorphic transformations; Indomethacin; Caffeine
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We show in this paper the contribution of the whole Raman spectrum including the phonon spectrum, to detect, identify and characterize polymorphic forms of molecular compounds, and study their stability and transformation. Obtaining these kinds of information is important in the area of pharmaceutical compounds. Two different polymorphic systems are analyzed through investigations in indomethacin and caffeine exposed to variable environmental conditions and various stresses, as possibly throughout the production cycle of the active pharmaceutical ingredient. It is shown the capability of the low-frequency Raman spectroscopy to reveal disorder in the crystalline state, to detect small amorphous or crystalline material, and to elucidate ambiguous polymorphic or polyamorphic situations. (C) 2011 Elsevier B.V. All rights reserved.
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