Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 395, Issue 1-2, Pages 260-265Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2010.05.018
Keywords
Tube-in-tube microchannel reactor; Cefuroxime axetil; Nanoparticles; High throughput; Micromixing
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Funding
- National 863 Program of China [2007AA030207, 2009AA033301]
- National Natural Science Foundation of China [20806004, 20821004]
- Program for New Century Excellent Talents in University of China [NCET-07-0053]
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This article presents the preparation of nanoparticles of amorphous cefuroxime axetil (CFA) in a microporous tube-in-tube microchannel reactor (MTMCR). The experimental results indicated that CFA particle with a tunable size of 400-1400 nm could be achieved under a high throughput in the range of 1.5-6 L/min. The average particle size decreased with increasing overall volumetric flow rate and decreasing CFA concentration, micropore size, and annular channel width. The produced CFA nanoparticles were characterized by SEM, XRD, FT-IR. DSC and a dissolution test, which indicated that the nanosized CFA was amorphous and exhibited higher dissolution rate compared to the raw CFA. The MTMCR might offer a general and facile pathway for mass production of the nanoparticles of hydrophobic pharmaceuticals thanks to its high throughput capacity and excellent micromixing performance. Crown Copyright (C) 2010 Published by Elsevier B.V. All rights reserved.
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