Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 384, Issue 1-2, Pages 173-180Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2009.09.041
Keywords
Nanoparticles; Nanocrystals; Particle size; Poorly water-soluble drug; Dispersion; Particle engineering
Categories
Funding
- Korea Government (MEST) [2009-0079798]
- Human Resource Development BK21 (KRF)
- Ministry of Knowledge Economy (MKE)
- KOTEF
- National Research Foundation of Korea [2009-0079798] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Nano-comminution has successfully brought nanoparticle formulations of poorly soluble drugs to our daily life. The key for the successful nano-comminution of a drug is the choice of a proper polymeric steric stabilizer. To systematically elucidate the rationale of stabilizer selection, two types of helical amino acid copolymers, relatively hydrophilic and hydrophobic copolymers, were used in nano-comminution. The hydrophilic copolymers had lysine as their major component. The addition of relatively hydrophobic leucine and phenylalanine to them could not make significant changes in particle size. However, when a small amount of hydrophilic glutamic acid or lysine was added into elastin-like hydrophobic copolymers of valine, glycine, and proline, significant composition dependence was found. Therefore, specific interactions between the functional groups of polymers and drug surfaces seem to be important for successful nano-comminution. The stimuli responsive behavior of the hydrophobic copolymer induced the temperature dependence of particle size. (C) 2009 Elsevier B.V. All rights reserved.
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