Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 389, Issue 1-2, Pages 130-138Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2010.01.026
Keywords
Biodegradable; pH-sensitive; Dynamic sensitivity; Oral drug-delivery
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Funding
- National 863 project [2007AA021902]
- National Natural Science Foundation of China [NSFC20704027, NSFC30700996]
- Specialized Research Fund for the Doctoral Program of Higher Education [SRFDP 200806100065]
- New Century Excellent Talents in University [NCET-08-0371]
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In this work, a novel pH-sensitive hydrogels based on macromonomer of methoxyl poly(ethylene glycol) poly(caprolactone)-acryloyl chloride (MPEG-PCL-AC, PCE-AC), poly(ethylene glycol) methyl ether methacrylate (MPEGMA), and methacrylic acid (MAA) were successfully synthesized by heat-initiated free radical polymerization method. The obtained macromonomers and hydrogels were characterized by H-1 NMR and FT-IR. respectively. Morphology study, swelling behavior, in vitro drug release behavior, acute oral toxicity of hydrogels, and cytotoxicity of PCE-AC macromonomer were also investigated in this paper. Finally, the hydrogels demonstrated that the sharp change in different pH value, thus believing to be promising the suitability of the candidate for oral drug-delivery systems. (C) 2010 Elsevier B.V. All rights reserved.
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