Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 374, Issue 1-2, Pages 119-124Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2009.03.001
Keywords
Astaxanthin; Nanoencapsulation; Nanoparticles; Encapsulation; Controlled release; Thermal stability
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The encapsulation of astaxanthin into polymeric nanospheres by solvent displacement was compared for three chemically diverse polymers, namely: poly(ethylene oxide)-4-methoxycinnamoylphthaloyl-chitosan (PCPLC), poly(vinylalcohol-co-vinyl-4-methoxycinnamate) (PB4) and ethylcellulose (EC). Although capable of forming nanospheres themselves, EC could not encapsulate astaxanthin at all, whilst PB4 yielded a poor encapsulation efficiency. In contrast, PCPLC yielded reasonably good encapsulation efficiency (98%) at a loading of 40% (w/w). Moreover, the freeze-dried astaxanthin-encapsulated PCPLC nanospheres showed good dispersibility in water yielding stable aqueous suspensions of 300-320 nm nanoparticles. A steady release of astaxanthin from the nanospheres up to a maximum of similar to 85% payload over 60 min was also demonstrated, at least in acetone. NMR analysis indicated that after a two-hour-heating at 70 degrees C in an aqueous environment, PCPLC nanoencapsulated astaxanthin showed minimal heat degradation of olefinic functionality in contrast to that of the unencapsulated pigment molecules which were almost completely destroyed. (C) 2009 Elsevier B.V. All rights reserved.
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