Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 368, Issue 1-2, Pages 83-88Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2008.09.056
Keywords
Peeling tests; Adhesion; Adherence; Rheological behavior; Human skin; Synthetic skin; Wound dressings
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Funding
- Conseil Regional d'Aquitaine (fonds FEDER)
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This work deals with the rheological behavior and adherence properties of pressure sensitive adhesive formulations dedicated to medical applications. We have developed a specific viscoelastic substrate which mimics adhesion on human skin to measure the adherence properties of PSAs when they are stuck on the human skin. By comparing peeling results of PSAs, dedicated to medical applications, stuck on human skin and on this viscoelastic substrate we show that this substrate, based on a blend of natural proteins, presents a better representation of the interactions occurring at the skin/adhesive interface than conventional substrates used for peel test (i.e. glass and steel). (C) 2008 Elsevier B.V. All rights reserved.
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