Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 410, Issue C, Pages 73-77Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2015.01.002
Keywords
Caloric restriction; Bone turnover; Osteocalcin; 25-hydroxyvitamin D (250HD); Vitamin D supplementation
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Funding
- National Institutes of Health [RO1-AG12161, NJAES-0153866]
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The effect of vitamin D supplementation and caloric restriction (CR) on glycemic indices and osteocalcin (OC) is not clear. In this randomized controlled double blind trial, we examined whether vitamin D-3 supplementation at 2500 IU/d (D) or placebo has differential effects on markers of insulin sensitivity and bone turnover in overweight/obese postmenopausal women during 6 weeks of caloric restriction (weight loss; WL, n = 39) compared to weight maintenance (WM, n = 37). Seventy-six women (57 +/- 6 years) completed this study and the WL groups lost 4 +/- 1% of body weight. Baseline serum 25-hydroxyvitamin D (25OHD) was 24.8 +/- 5.6 ng/mL at baseline; the rise was greatest in WL-D group (p < 0.05). There was an interaction between vitamin D intake and weight on serum OC, insulin, glucose and markers of insulin sensitivity (p < 0.05). The change in OC was explained by changes in serum 25OHD and insulin (model R-2=25.6%). Overall, vitamin D supplementation and CR influence serum osteocalcin levels and modestly favor improvements in insulin sensitivity. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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