Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 365, Issue 1-2, Pages 81-88Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2008.08.026
Keywords
Salting-out effect; Taste masking; Numbness; Lag time; Immediate drug release; Multiparticulate dosage form
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Salting-out effects were utilized for developing a multi particulate system balancing numbness masking and high bioavailability. A salting-out taste-masking system consisting of a drug core containing acetaminophen as a model drug, a salting-out layer containing sodium carbonate (Na(2)CO(3)) and hydroxypropyl ypropylmethylcellulose (HPMC), and a water-penetration-control layer consisting of cetanol was designed and prepared. The system successfully generated a long lag time while achieving immediate drug release. In the system, the Na(2)CO(3) release rate was slower and the lag time was longer than when the water-penetration-control layer was not present. During the release of Na(2)CO(3) from the system, the release of HPMC and drug was suppressed. These results indicated that the water-penetration-control layer maintained a high concentration of Na(2)CO(3), prevented HPMC's dissolution, and generated a long lag time of drug release. The system generated longer lag time and released drug more immediately than formulation containing the water-penetration-control layer of same thickness without the salting-out layers. These results indicated the salting-out layers were necessary for obtain a long lag time and subsequent immediate drug release. This novel taste-masking system has the potential to be a useful multiparticulate dosage form for effective, safe, and user-friendly drug therapy. (C) 2008 Elsevier B.V. All rights reserved.
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