Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 415, Issue C, Pages 87-99Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2015.08.008
Keywords
gsdf; Sex differentiation; Sex determination; dmrt1; Nile tilapia
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Funding
- SORST, JST (Japan Science and Technology Corporation) [KAKENHI 24370028, KAKENHI 26292109]
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The Nile tilapia, Oreochromis niloticus, is a gonochoristic teleost fish with an XX/XY genetic system and is an excellent model for gonadal sex differentiation. In the present study, we screened novel genes that were expressed predominantly in either XY or XX undifferentiated gonads during the critical period for differentiation of gonads into ovaries or testes using microarray screening. We focused on one of the isolated 12 candidate genes, #9475, which was an ortholog of gsdf (gonadal soma-derived factor), a member of the transforming growth factor-beta superfamily. #9475/gsdf showed sexual dimorphism in expression in XY gonads before any other testis differentiation-related genes identified in this species thus far. We also overexpressed the #9475/gsdf gene in)0( tilapia, and XX tilapia bearing the #9475/gsdf gene showed normal testis development, which suggests that #9475/gsdf plays an important role in male determination and/or differentiation in tilapia. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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