Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 349, Issue 1-2, Pages 269-273Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2007.08.003
Keywords
progesterone; polymeric additives; microemulsion; stability; skin permeation
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The influence of progesterone on the physicochemical behaviour of the o/w microemulsion consisting of the non-ionic surfactant polyoxyethylene-10-dodecyl ether, tributyrin and water was investigated. Thereby no significant influence could be detected in terms of droplet size, zeta potential, conductivity and pH by progesterone. However the chemical stability of progesterone was insufficient during the storage of 6 months. Therefore, two different polymeric agents, named silicon dioxide and polymeric emulsifier, were added to the progesterone containing microemulsions. These polymers increased the chemical stability of progesterone significantly. Moreover the polymeric additives improved the skin permeation 1.24- and 1.63-fold and decreased the skin retention in relation to the pure microemulsion. The polymer-stabilized progesterone microemulsions are interesting vehicles for skin application of progesterone. (c) 2007 Elsevier B.V. All rights reserved.
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