Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 411, Issue C, Pages 20-27Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2015.04.007
Keywords
Adipocyte differentiation; Adipose tissue; Aldosterone; IL-33/ST2 system
Categories
Funding
- INSERM
- Programme National de Recherche Cardiovasculaire
- Region Lorraine
- Fondo de Investigaciones Sanitarias [PI12/01729]
- Red de Investigacion Cardiovascular [RD12/0042/0033]
- Miguel Servet Programme [CP13/00221]
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Interleukin-33 (IL-33) but not soluble ST2 (sST2) exerts anti-inflammatory and protective effects in several tissues. Aldosterone, a proinflammatory mediator which promotes adipogenesis, is elevated in obese patients. The aim of this study was to investigate the interactions between IL-33/ST2 system and Aldosterone in adipose tissue. Rats fed a high fat diet presented increased sST2 expression, diminished IL-33/5ST2 ratio and enhanced levels of differentiation and inflammation in adipose tissue as compared to controls. A similar pattern was observed in adipose tissue from C57BL/6 Aldosterone-treated mice. In both animal models, Aldosterone was correlated with sST2. Treatment of 3T3-L1 adipocytes with IL-33 delayed adipocyte differentiation diminished lipid accumulation and decreased inflammation. Aldosterone decreased IL-33 and increased sST2 expressions in differentiated adipocytes. Aldosterone-induced adipocyte differentiation and inflammation were blocked by IL-33 treatment, but sST2 did not exert any effects. The crosstalk between IL-33/ST2 and Aldosterone could be relevant in the metabolic consequences of obesity. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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