Journal
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
Volume 20, Issue 4, Pages 427-434Publisher
SPRINGER
DOI: 10.1007/s10989-014-9402-3
Keywords
bFGF; bFGF-binding peptide; Apoptosis; Drug resistance
Categories
Funding
- National Natural Science Foundation of China [81071800]
- Natural Science Foundation of Zhejiang Province of China [Y14H310037]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
- Team Project of Natural Science Foundation of Guangdong Province of China [S2013030013315]
- Fundamental Research Funds for the Central Universities
- Guangdong Provincial Thousand-Hundred-Ten Talent Project
- Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Jinan University
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Development of drug resistance is a challenging problem in cancer chemotherapy. It has been shown that basic fibroblast growth factor (bFGF) plays an important role in an epigenetic mechanism of drug resistance. We have isolated a bFGF binding peptide P7 with inhibitory activity against bFGF-induced proliferation of human gastric cancer cells by screening a phage display library. In this study, we found that P7 peptide also has efficacy of reversing bFGF-induced resistance to Adriamycin (ADM) in human gastric cancer cells. Further investigations with SGC-7901 cells revealed that inhibition of Akt activation triggered by bFGF, and reversal of bFGF-induced up-regulation of Bcl-2 and XIAP and down-regulation of Bax, contribute to P7 peptide counteracting the anti-apoptotic effect of bFGF, and further reversing bFGF-induced resistance to ADM. The results suggested that the bFGF-binding peptide may have therapeutic potential of drug resistance in gastric cancer.
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