Vitamin D and tonsil disease - Preliminary observations

Objective: To estimate the prevalence of 25(OH) vitamin D deficiency in children undergoing (adeno)tonsillectomy. Methods: From 1st November 2008 to 20th December 2008,33 children aged from 4 to 16 and resident in Auckland, New Zealand (latitude 36 degrees 52` S) undergoing (adeno)tonsillectomy for difficulty breathing/sleep apnoea and/or recurrent tonsillitis had 25(OH) vitamin D, iron and zinc levels measured. Results: Of the 32 patients who had 25(OH) vitamin D levels measured, 15.6% were vitamin D deficient (25(OH) vitamin D < 50 nmol/L), and 78% had levels, < 75 nmol/L 25(OH) vitamin D level was inversely correlated with Fitzpatrick skin type (Spearman's rho = -0.713, p < 0.01), body mass index (BMI) (Spearman's rho = -0.434, p = 0.013) and tonsil size (Spearman's rho = -0.417, p 0.017). However regression modeling demonstrated that only Fitzpatrick skin type (beta = -0.687, p = 0.001) and BMI (beta = -0.256, p = 0.044) were significant predictors of vitamin D levels (R-2 = 0.572). Conclusions: Seventy-eight percent of Auckland children undergoing (adeno)tonsillectomy had a 25(OH) vitamin D level < 75 nmol/L, a level which is associated with an increased incidence of upper respiratory tract infection. Low 25(OH) vitamin D levels were related to a darker skin, increased BMI and larger assessed tonsil size. The association of larger tonsil size with lower 25(OH) vitamin D status needs further evaluation but offers a potential explanation why black and Hispanic children are more likely than white children to have (adeno)tonsillectomy for snoring or obstructive sleep apnoea. (c) 2010 Elsevier Ireland Ltd. All rights reserved.