Journal
MOLECULAR & CELLULAR PROTEOMICS
Volume 14, Issue 12, Pages 3105-3117Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/mcp.O115.052431
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Funding
- Marie Curie Intra-European Fellowship
- ERC grant Proteomics v3.0 [ERC-2008-AdG_20080422]
- ERC Proteomics 4D [670821]
- Swiss National Science Foundation [3100A0-688 107679]
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The myriad of peptides presented at the cell surface by class I and class II major histocompatibility complex (MHC) molecules are referred to as the immunopeptidome and are of great importance for basic and translational science. For basic science, the immunopeptidome is a critical component for understanding the immune system; for translational science, exact knowledge of the immunopeptidome can directly fuel and guide the development of next-generation vaccines and immunotherapies against autoimmunity, infectious diseases, and cancers. In this mini-review, we summarize established isolation techniques as well as emerging mass spectrometry-based platforms (i.e. SWATH-MS) to identify and quantify MHC-associated peptides. We also highlight selected biological applications and discuss important current technical limitations that need to be solved to accelerate the development of this field.
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