Journal
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
Volume 37, Issue 3, Pages 264-268Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.ijom.2007.11.011
Keywords
serrapeptase; postoperative; pain; swelling; trismus; third molar
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The aim of this study was to investigate the ability of serrapeptase to reduce postoperative swelling, pain and trismus after third molar surgery. Twenty-four healthy individuals with symmetrically impacted mandibular third molars underwent surgical removal in a prospective, intra-individual, randomized, double-blind, cross-over study. Teeth were removed in 2 sessions by the same surgeon. At each session, one third molar was removed under local anaesthesia via a buccal osteotomy. All patients received a combination of either serrapeptase 5 mg or placebo tablets and 1000 mg paracetamol tablets at either the 1 st or 2nd operation in accordance with the randomization plan. Cheek thickness, pain and interincisal distance were measured preoperatively, and on the I st, 2nd, 3rd and 7th postoperative days. Cheek thickness and maximum interincisal distance were measured using calipers. Pain intensity was assessed clinically using a numeric scale. There was a significant reduction in the extent of check swelling and pain intensity in the serrapeptase group at the 2nd, 3rd and 7th postoperative days (P < 0.05), but no significant difference in mean maximal interincisal distance was found between the 2 groups (P > 0.05).
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