Journal
INTERNATIONAL JOURNAL OF ONCOLOGY
Volume 46, Issue 2, Pages 548-554Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2014.2783
Keywords
prostaglandin I-2; metastasis; maturation; pericytes; hypoxia
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Funding
- JSPS [20590910]
- Grants-in-Aid for Scientific Research [24591147, 20590910, 24591031] Funding Source: KAKEN
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Prostaglandin I-2 (PGI(2)) agonist has been reported to reduce tumor metastasis by modifying tumor angiogenesis; however, the mechanisms of how PGI(2), affects the endothelial cells or pericytes in tumor vessel maturation are still unclear. The purpose of this study was to clarify the effects of PGI(2), on tumor metastasis in a mouse lung metastasis model using Lewis lung carcinoma (LLC) cells. The mice were treated continuously with beraprost sodium (BPS), a PGI(2), analog, for 3 weeks and then examined for lung metastases. The number and size of lung metastases were decreased significantly by BPS treatment. In addition, scanning electron microscopy and immunohistochemistry revealed that BPS increased the number of tumor-associated pericytes and improved intratumor hypoxia. Collectively, this study suggests that BPS attenuated vascular functional maturation in metastatic tumors.
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