Journal
INTERNATIONAL JOURNAL OF ONCOLOGY
Volume 45, Issue 6, Pages 2187-2192Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2014.2678
Keywords
AKT; gastric cancer; human telomerase reverse transcriptase
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Funding
- Grants-in-Aid for Scientific Research [25670177] Funding Source: KAKEN
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AKT is a serine/threonine kinase activated downstream of integrin, which is a receptor for various pro-proliferation and bioactive substances as well as the extracellular matrix receptor. The activation of AKT often contributes to tumorigenesis and plays a role in regulating cell motility, which is critical for local invasion and metastasis. In recent years, it has also drawn attention as a target of new molecular-targeted agents. When analyzing the role of AKT in cancer cells, it is important to consider the microenvironment and variations of cancers. In this review, a basic overview of the role of AKT in normal and malignant tissues is provided, along with an in-depth discussion of its role in gastric cancer and its potential as a target for therapy.
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