Journal
INTERNATIONAL JOURNAL OF ONCOLOGY
Volume 42, Issue 4, Pages 1181-1188Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2013.1818
Keywords
p53 family; isoform; biomarker; poor prognosis; liver fluke; cholangiocarcinoma
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Funding
- Higher Education Research Promotion and National Research University Project of Thailand, Office of the Higher Education Commission, through the Health Cluster (SHeP-GMS), Khon Kaen University
- Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences
- Graduate School, Khon Kaen University, Khon Kaen, Thailand
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All p53 family members are expressed in several isoforms through alternative promoters and alternative splicing. However, the significance of these isoforms is not yet well understood in cholangiocarcinoma (CCA). In this study, we investigated the expression of p53, p63, p73 and their isoforms at the mRNA and protein levels in CCA. The overexpression of Delta 133p53 was observed in the CCA cell lines and clinical specimens. Moreover, the high expression of Delta 133p53/TAp53 correlated with short overall survival (p<0.001). Defective p53, including mutant and Delta Np53, was associated with poor prognosis (p<0.024). Multivariate analysis demonstrated that Delta 133p53/TAp53 and mutant p53 protein may be used as independent prognostic factors for CCA. To our knowledge, this is the first report of the use of Delta 133p53/TAp53 as a potential biomarker in CCA.
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