Journal
INTERNATIONAL JOURNAL OF ONCOLOGY
Volume 43, Issue 1, Pages 194-200Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2013.1920
Keywords
alternative splicing; prostate cancer; apoptosis; caspase 9; flavonoids; epigallocatechin-3-gallate
Categories
Funding
- QR (University of the West of England, Bristol, UK)
- Royal Society International Travel Grant [TG092176]
Ask authors/readers for more resources
Growing evidence suggests that the flavonoid epigallocatechin-3-gallate (EGCG), notably abundant in green tea, has health-promoting properties. We examined the effect of EGCG on cell survival and apoptosis in the prostate cancer cell line PC3. Cell survival was reduced and apoptosis increased significantly with a low dose of 1 mu M EGCG. The ability of the anticancer drug cisplatin to promote apoptosis was enhanced by EGCG. Furthermore, EGCG, both alone and in combination with cisplatin, promoted the expression of the pro-apoptotic splice isoform of caspase 9.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available