Journal
INTERNATIONAL JOURNAL OF OBESITY
Volume 37, Issue 4, Pages 598-603Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ijo.2012.88
Keywords
copeptin; arginine vasopressin; abdominal obesity; diabetes; metabolic syndrome; microalbuminuria
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Funding
- European Research Council [StG-282255]
- Swedish Medical Research Council
- Swedish Heart and Lung Foundation
- Medical Faculty of Lund University
- Malmo University Hospital
- Albert Pahlsson Research Foundation
- Crafoord Foundation
- Ernhold Lundstroms Research Foundation
- Region Skane
- Hulda and Conrad Mossfelt Foundation
- King Gustaf V and Queen Victoria Foundation
- Lennart Hanssons Memorial Fund
- Wallenberg Foundation
- Novo Nordisk Fonden [NNF13OC0005339] Funding Source: researchfish
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BACKGROUND: High plasma copeptin (copeptin), the C-terminal fragment of arginine vasopressin pro-hormone, has been associated with the metabolic syndrome (MetS), diabetes mellitus (DM) development and nephropathy. Here we tested whether elevated copeptin level is associated with later development of the MetS, its individual components and microalbuminuria. METHODS: We analysed copeptin at baseline (1991-1994) in the population-based Malmo Diet and Cancer Study cardiovasular cohort and re-examined 2064 subjects 15.8 years later (mean age 72.8 years, 59% women) with oral glucose tolerance test and measurement of MetS and its individual components. RESULTS: After age and sex adjustment, increasing quartiles of copeptin at baseline (the lowest quartile as reference) were associated with MetS (P for trend = 0.008), incident abdominal obesity (P for trend = 0.002), DM (P for trend = 0.001) and microalbuminuria (P for trend = 0.002). After additional adjustment for all the MetS components at baseline, increasing copeptin quartiles predicted incident abdominal obesity (odds ratios 1.55, 1.30 and 1.59; P for trend = 0.04), DM (odds ratios 1.18, 1.32 and 1.46; P for trend 0.04) and microalbuminuria (odds ratios 1.05, 1.08 and 1.65; P for trend = 0.02) but not MetS (P for trend = 0.19) at the reexamination. Further, the relationship between copeptin and microalbuminuria was independent of baseline C-reactive protein, incident DM and incident hypertension. CONCLUSION: Copeptin independently predicts DM and abdominal obesity but not the cluster of MetS. Apart from predicting DM and abdominal obesity, elevated copeptin signals increased risk of microalbuminuria. Interestingly, the association between copeptin and later microalbuminuria was independent of both prevalent and incident DM and hypertension. Our findings suggest a relationship between a dysregulated vasopressin system and cardiometabolic risk, which could have implications for risk assessment and novel preventive treatments. International Journal of Obesity (2013) 37, 598-603; doi:10.1038/ijo.2012.88; published online 22 May 2012
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