Journal
INTERNATIONAL JOURNAL OF OBESITY
Volume 36, Issue 3, Pages 440-447Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ijo.2011.114
Keywords
colorectal adenoma; insulin; insulin-like growth factor; insulin-like growth factor-binding protein; case-control studies
Categories
Funding
- Ministry of Health, Labour and Welfare of Japan
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [17015049, 19689014, 22790579]
- Grants-in-Aid for Scientific Research [19689014, 22790579, 221S0001] Funding Source: KAKEN
Ask authors/readers for more resources
Objective: Accumulating evidence has implicated insulin and the insulin-like growth factor (IGF) axis in colorectal carcinogenesis. Of interest, adiposity is likely to impose a greater risk on men than on women, which indicates that the association of insulin and the IGF axis with colorectal neoplasia may differ by gender. However, epidemiological evidence for this possible gender difference is limited to date. Methods: We measured plasma concentrations of C-peptide, IGF-I and IGF-binding proteins (IGFBPs) 1 and 3 in 1520 healthy volunteer examinees who underwent total colonoscopy between February 2004 and February 2005, and cross-sectionally investigated the association of these biomarkers with colorectal adenoma by gender. An unconditional logistic regression model was used to estimate odds ratios (ORs) and their 95% confidence intervals (CIs) for colorectal adenoma after adjustment for potential confounders. Results: We observed a positive association of C-peptide and IGF-I (P-trend<0.001 and 0.02, respectively) and an inverse association of IGFBP-1 (P-trend=002) with colorectal adenoma in men. Adjusted ORs of colorectal adenoma for the highest compared with the lowest quartile were also statistically significant for C-peptide (OR: 2.62, 95% CI: 1.71-4.01), IGF-I (OR: 1.63, 95% CI: 1.08-2.46) and IGFBP-1 (OR: 0.49, 95% CI: 0.32-0.75). In contrast, no measurable association was seen in women. Corresponding ORs for C-peptide, IGF-I and IGFBP-1 were 0.98 (95% CI: 0.56-1.71), 0.79 (95% CI: 0.44-1.43) and 1.05 (95% CI: 0.60-1.86), respectively. The gender difference was statistically significant for C-peptide (P-interaction=0.03) and marginally significant for IGF-I and IGFBP-1 (P-interaction=0.14 and 0.12, respectively). Conclusion: Our observations suggest that insulin and the IGF axis act differently by gender in colorectal carcinogenesis, at least in its early stage. The findings of this study further our understanding of the complexities of the gender difference in the association between adiposity and colorectal neoplasia. International Journal of Obesity (2012) 36, 440-447; doi:10.1038/ijo.2011.114; published online 14 June 2011
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available