Journal
INTERNATIONAL JOURNAL OF NEUROSCIENCE
Volume 124, Issue 12, Pages 944-946Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/00207454.2014.890934
Keywords
experimental model; Alzheimer's disease (AD); streptozotocin (STZ)
Categories
Ask authors/readers for more resources
The in vivo experimental simulation of Alzheimer's disease (AD) has been a field of paramount importance for Experimental Medicine and Neuroscience for more than 20 years. We herein provide a short overview of an experimental approach to sporadic AD that is based on the insulin-resistant state induced in the brains of animals following the intracerebroventricular (icv) administration of streptozotocin (STZ) at low doses. The icv administration of STZ is considered as an established, standardized and reproducible approach to sporadic AD, central aspects of the pathology of which it can reliably simulate.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available