Journal
INTERNATIONAL JOURNAL OF NEUROSCIENCE
Volume 124, Issue 5, Pages 307-321Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/00207454.2013.833510
Keywords
Microglia; neuroinflammation; beta-amyloid; Alzheimer's disease
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Funding
- Provincial Nature Science Foundation of Anhui [1308085MH158]
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Compelling evidence from basic molecular biology has demonstrated the dual roles of microglia in the pathogenesis of Alzheimer's disease (AD). On one hand, microglia are involved in AD pathogenesis by releasing inflammatory mediators such as inflammatory cytokines, complement components, chemokines, and free radicals that are all known to contribute to beta-amyloid (A beta) production and accumulation. On the other hand, microglia are also known to play a beneficial role in generating anti-A beta antibodies and stimulating clearance of amyloid plaques. A beta itself, an inducer of microglia activation and neuroinflammation, has been considered as an underlying and unifying factor in the development of AD. A vicious cycle of inflammation has been formed between A beta accumulation, activated microglia, and microglial inflammatory mediators, which enhance A beta deposition and neuroinflammation. Thus, inhibiting the vicious cycle seems to be a promising treatment to restrain further development of AD. With increasing research efforts on microglia in AD, intervention of microglia activation and neuroinflammation in AD may provide a potential target for AD therapy in spite of the provisional failure of nonsteroidal antiinflammatory drugs in clinical trials.
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