Journal
INTERNATIONAL JOURNAL OF NEUROSCIENCE
Volume 121, Issue 2, Pages 51-57Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/00207454.2010.535934
Keywords
Acid lipoic; antioxidant; neuroprotective; oxidative stress; Parkinson's disease; treatment
Categories
Funding
- FUNCAP
- CAPES
- CNPq
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This work reviews the evidence of the mechanism of neuronal degeneration in Parkinson's disease (PD) and the neuroprotective effect of lipoic acid and its use in the treatment of PD. PD is characterized by slow and progressive degeneration of dopaminergic neurons of the substantia nigra pars compacta, leading to reduction of the striatal dopaminergic terminals. It is known that several factors influence neuronal damage. Among these factors, oxidative stress, immune system activity, microglial cells, and apoptotic mechanisms are of major importance. Currently, several antioxidants have been studied with the aim of reducing/slowing the progression of neurodegenerative processes. Lipoic acid is considered a universal antioxidant because it is an amphipathic substance. Lipoic acid and its reduced form, dihidrolipoic acid, act against reactive oxygen species, reducing oxidative stress. Therefore, this antioxidant has been used in the treatment of many diseases, including a new perspective for the treatment of Parkinson's disease.
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