Journal
INTERNATIONAL JOURNAL OF NEUROSCIENCE
Volume 118, Issue 11, Pages 1582-1593Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/00207450701392282
Keywords
magnetic resonance imaging; brain; obesity
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Funding
- NIA NIH HHS [R01 AG017975] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [R01AG017975] Funding Source: NIH RePORTER
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There is a growing evidence that elevated body mass index (BMI) is associated with adverse neurocognitive outcome, though no study has examined whether morphometric differences are found in persons across the adult life span. We compared 201 healthy individuals in normal weight, overweight, and obese groups (aged 17-79). After correcting for demographic differences, obese individuals showed smaller whole brain and total gray matter volume than normal weight and overweight individuals. These findings support an independent relationship between BMI and brain structure and demonstrate that these differences are not limited to older adults.
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