Journal
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
Volume 16, Issue 7, Pages 1569-1575Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1461145712001563
Keywords
5-HT2A receptors; atypical antipsychotic drug; dopamine; opiate; serotonin
Funding
- National Basic Research Program of China [2009CB522008]
- Nature Science Foundation of China [U1132602, 81071077]
- Zhejiang Province [D2080515, 2010R10058, 201101A6110048]
- K. C. Wong Magna Fund in Ningbo University
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The aim of the present study was to investigate the effects of pretreatment with risperidone on heroin self-administration and heroin-seeking behaviour induced by cues and heroin priming. Rats were trained to self-administer heroin under a fixed ratio 1 schedule for 2 wk and nose-poke responding was extinguished for 10 d, after which reinstatement of drug seeking was induced by conditioned cues or heroin priming. Acute risperidone administration at doses 10-100 mu g/kg potently and dose-dependently inhibited reinstatement of conditioned cue-induced heroin seeking; the minimum dose of inhibition was 30 mu g/kg. In contrast, risperidone at the same doses did not attenuate reinstatement induced by two priming doses of heroin (100 or 250 mu g/kg s.c.). Risperidone at these doses failed to alter heroin self-administration and locomotion activity. These data demonstrate that acute treatment with low-dose risperidone inhibits conditioned cue-induced heroin seeking and risperidone may be an adjunctive therapy for the treatment of heroin addiction.
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