Journal
MITOCHONDRION
Volume 25, Issue -, Pages 67-75Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2015.10.001
Keywords
Mitochondrial biogenesis; MtDNA; TFAM; TFAM-mtDNA interactions; Aging; Calorie restriction
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Mitochondrial biogenesis is regulated to adapt mitochondrial population to cell energy demands. Mitochondrial transcription factor A (TFAM) performs several functions for mtDNA and interactions between TFAM and mtDNA participate to regulation of mitochondrial biogenesis. Such interactions are modulated through different mechanisms: regulation of TFAM expression and turnover, modulation of TFAM binding activity to mtDNA through post-translational modifications and differential affinity of TFAM, occurrence of TFAM sliding on mtDNA filaments and of cooperative binding among TFAM molecules, modulation of protein-protein interactions. The tissue-specific regulation of mitochondrial biogenesis in aging and calorie restriction (CR) highlights the relevance of modulation of TFAM-mtDNA interactions. (C) 2015 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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