Journal
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
Volume 12, Issue 2, Pages 217-226Publisher
OXFORD UNIV PRESS
DOI: 10.1017/S1461145708008778
Keywords
Dopamine receptors; food deprivation; relapse; reinstatement; stress
Funding
- Natural Science and Engineering Council of Canada (NSERC)
- Canada Research Chair (CRC)
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Dopan-Line has a critical role in drug reinforcement and the reinstatement of drug seeking due to priming or exposure to drug-associated cues. In contrast, the role of dopamine in stress-induced reinstatement is not clear. We have previously demonstrated that acute food deprivation, a clinically relevant stressor, reinstates heroin seeking in rats via a leptin-dependent mechanism. Recent reports have suggested a modulating role for leptin on dopamine transmission and drug-related behaviours. Thus, here we investigated the role of dopamine in acute food deprivation-induced reinstatement of heroin seeking. Rats were trained to self-administer heroin (0.05 mg/kg per infusion) for 10 d. Following training, heroin seeking was extinguished and rats were tested for 48-h food deprivation-induced reinstatement while pretreated with the dopamine D-1-, D-2-, or D-3-like receptor antagonists: SCH 23390 (0.0, 5.0 or 10.0 mu g/kg), raclopride (0.0, 50.0 or 100.0 mu g/kg) or NGB 2904 (0.0, 0.1 or 5.0 mg/kg), respectively. The dopamine D-1-like receptor antagonist, SCH 23390, but neither of the other antagonists, showed a dose-dependent attenuation of food deprivation-induced reinstatement. Our results suggest that acute food deprivation-induced reinstatement may be mediated, at least in part, by activation of the dopamine D-1-like receptor.
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