Journal
INTERNATIONAL JOURNAL OF NANOTECHNOLOGY
Volume 10, Issue 10-11, Pages 959-972Publisher
INDERSCIENCE ENTERPRISES LTD
DOI: 10.1504/IJNT.2013.058122
Keywords
nanotechnology; electrospinning; controlled release; drug delivery; biomaterials
Funding
- National Taiwan University of Science and Technology
- National Science Council of Taiwan [NSC-101-2221-E-011-053-, NSC-102-2221-E-011-070-]
Ask authors/readers for more resources
This study demonstrates a facile and general method developed to prepare a free-standing chitosan/polycaprolactone nonwoven mat (CS/PCLNM) using an electrospinning system equipped with a metallic frame with an air gap. All nonwoven mats are composed of polycaprolactone microfibres coated with a layer of CS or tea tree oil containing-CS (TTO-CS/PCLNM). Four bacteria commonly associated with human skin flora infections or hospital-acquired infections were chosen as the targets for our in vitro anti-bacterial susceptibility testing (P. aeruginosa, M. luteus, S. pyogenes, and S. aureus). The bacteriostatsis ratios of the CS/PCLNM against above mentioned bacteria are -77.2%, -67.5%, 99.9%, and 86.4%, respectively. In addition, we find that the anti-bacterial ability of the CS/PCLNM is further promoted by incorporating a 100 mu L of TTO in its CS overlayer. After TTO incorporation, the produced TTO-CS/PCLNM shows anti-bacterial ability against all four strains of bacteria (P. aeruginosa: 99.8%, M. luteus: 12.8%, S. pyogenes: 96.7%, and S. aureus: 99.9%). In conclusion, the TTO-CS/PCLNM exhibits broader anti-bacterial spectrum than that of the CS/PCLNM toward commonly seen skin flora.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available