Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 9, Issue -, Pages 2597-2605Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S59654
Keywords
capped mesoporous nanoparticles; intracellular release; pH-responsive nanoparticles; Saccharomyces cerevisiae; tebuconazole loading
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pH-sensitive gated mesoporous silica nanoparticles have been synthesized. Increased extracellular pH and internalization into living yeast cells triggered molecular gate aperture and cargo release. Proper performance of the system was demonstrated with nanodevices loaded with fluorescein or with the antifungal agent tebuconazole. Interestingly, nanodevices loaded with tebuconazole significantly enhanced tebuconazole cytotoxicity. As alterations of acidic external pH are a key parameter in the onset of fungal vaginitis, this nanodevice could improve the treatment for vaginal mycoses.
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