Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 9, Issue -, Pages 2069-2072Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S64301
Keywords
in vivo clearance; gold nanoparticles; small size
Funding
- National Natural Science Foundation of China [81000668]
- Natural Science Foundation of Tianjin [13JCQNJC13500]
- Subject Development Foundation of Institute of Radiation Medicine, CAMS [SF1207, SZ1336]
- Fundamental Research Funds for the Central Universities [3332013043]
- PUMC Youth Fund
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The use of nanoparticles holds promise for medical applications, such as X-ray imaging, photothermal therapy and radiotherapy. However, the in vivo toxicity of inorganic nanoparticles raises some concern regarding undesirable side effects which prevent their further medical application. Ultrasmall sub-5.5 nm particles can pass through the barrier for renal clearance, minimizing their toxicity. In this letter we address some recent interesting work regarding in vivo toxicity and renal clearance, and discuss the possible strategy of utilizing ultrasmall nanomaterials. We propose that small hydrodynamic sized nanoclusters can achieve both nontoxic and therapeutic clinical features.
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