Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 7, Issue -, Pages 3719-3730Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S32824
Keywords
magnetism; mesenchymal stem cell; nanoparticle; spinal cord injury; modeling
Funding
- Grant Agency of the Czech Republic [P304/12/1370, P304/11/0731, P304/11/0189, P304/11/0653]
- Grant Agency of the Academy of Sciences of the Czech Republic [AVOZ50390703, IAA500390902, AV0Z10100522]
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The transplantation of mesenchymal stem cells (MSC) is currently under study as a therapeutic approach for spinal cord injury, and the number of transplanted cells that reach the lesioned tissue is one of the critical parameters. In this study, intrathecally transplanted cells labeled with superparamagnetic iron oxide nanoparticles were guided by a magnetic field and successfully targeted near the lesion site in the rat spinal cord. Magnetic resonance imaging and histological analysis revealed significant differences in cell numbers and cell distribution near the lesion site under the magnet in comparison to control groups. The cell distribution correlated well with the calculated distribution of magnetic forces exerted on the transplanted cells in the subarachnoid space and lesion site. The kinetics of the cells' accumulation near the lesion site is described within the framework of a mathematical model that reveals those parameters critical for cell targeting and suggests ways to enhance the efficiency of magnetic cell delivery. In particular, we show that the targeting efficiency can be increased by using magnets that produce spatially modulated stray fields. Such magnetic systems with tunable geometric parameters may provide the additional level of control needed to enhance the efficiency of stem cell delivery in spinal cord injury.
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