Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 7, Issue -, Pages 2557-2571Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S29145
Keywords
cross-linked micelle; cisplatin; ovarian cancer; block ionomer complex; drug delivery
Funding
- USA National Institutes of Health [CA116590]
- NIH [1P20RR021937]
- USA NSF [0411164]
- NATIONAL CANCER INSTITUTE [R01CA116590] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR021937] Funding Source: NIH RePORTER
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Polymer micelles with cross-linked ionic cores are shown here to improve the therapeutic performance of the platinum-containing anticancer compound cisplatin. Biodistribution, antitumor efficacy, and toxicity of cisplatin-loaded core cross-linked micelles of poly(ethylene glycol)-b-poly(methacrylic acid) were evaluated in a mouse ovarian cancer xenograft model. Cisplatin-loaded micelles demonstrated prolonged blood circulation, increased tumor accumulation, and reduced renal exposure. Improved antitumor response relative to free drug was seen in a mouse model. Toxicity studies with cisplatin-loaded micelles indicate a significantly improved safety profile and lack of renal abnormalities typical of free cisplatin treatment. Overall, the study supports the fundamental possibility of improving the potential of platinum therapy using polymer micelle-based drug delivery.
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