4.7 Article

Nanoparticles of carbon allotropes inhibit glioblastoma multiforme angiogenesis in ovo

Journal

INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 6, Issue -, Pages 3041-3048

Publisher

DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S25528

Keywords

cancer; nanoparticle; embryo; angiogenesis; FGF-2; VEGF

Funding

  1. New, multifunctional nanopowder of carbon [357/ERA-NET]
  2. Danish Agency for Science Technology and Innovation [2106-08-0025]

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The objective of the study was to determine the effect of carbon nanoparticles produced by different methods on the growth of brain tumor and the development of blood vessels. Glioblastoma multiforme cells were cultured on the chorioallantoic membrane of chicken embryo and after 7 days of incubation, were treated with carbon nanoparticles administered in ovo to the tumor. Both types of nanoparticles significantly decreased tumor mass and volume, and vessel area. Quantitative real-time polymerase chain reaction analysis showed downregulated fibroblast growth factor-2 and vascular endothelial growth factor expression at the messenger ribonucleic acid level. The present results demonstrate antiangiogenic activity of carbon nanoparticles, making them potential factors for anticancer therapy.

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