Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/ijms19092732
Keywords
sterile liver inflammation; NLRP3 inflammasome; IL-1 beta; IL-33; ILC2; tregs
Funding
- Deutsche Forschungsgemeinschaft (DFG): The Priority Programme Innate lymphoid cells (SPP 1937)
- Deutsche Forschungsgemeinschaft (DFG) [SFB 841]
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In sterile liver inflammation, danger signals are released in response to tissue injury to alert the immune system; e.g., by activation of the NLRP3 inflammasome. Recently, IL-33 has been identified as a novel type of danger signal or alarmin, which is released from damaged and necrotic cells. IL-33 is a pleiotropic cytokine that targets a broad range of immune cells and exhibits pro-and anti-inflammatory properties dependent on the disease. This review summarizes the immunomodulatory roles of the NLRP3 inflammasome and IL-33 in sterile liver inflammation and highlights potential therapeutic strategies targeting these pathways in liver disease.
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