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Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors
Antonio Jimeno et al.
CLINICAL CANCER RESEARCH (2013)
Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo
Malin Wickstrom et al.
INTERNATIONAL JOURNAL OF CANCER (2013)
MicroRNA 218 Acts as a Tumor Suppressor by Targeting Multiple Cancer Phenotype-associated Genes in Medulloblastoma
Sujatha Venkataraman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Tissue-Derived Hedgehog Proteins Modulate Th Differentiation and Disease
Anna L. Furmanski et al.
JOURNAL OF IMMUNOLOGY (2013)
Hh signaling inhibitors from Vitex negundo; naturally occurring inhibitors of the GLI1-DNA complex
Midori A. Arai et al.
MOLECULAR BIOSYSTEMS (2013)
Noncanonical Regulation of the Hedgehog Mediator GLI1 by c-MYC in Burkitt Lymphoma
Joon Won Yoon et al.
MOLECULAR CANCER RESEARCH (2013)
GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas
Scott X. Atwood et al.
NATURE (2013)
The mechanisms of Hedgehog signalling and its roles in development and disease
James Briscoe et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function
S. Pandolfi et al.
ONCOGENE (2013)
Imiquimod directly inhibits Hedgehog signalling by stimulating adenosine receptor/protein kinase A-mediated GLI phosphorylation
F. Wolff et al.
ONCOGENE (2013)
Gli as a Novel Therapeutic Target in Malignant Pleural Mesothelioma
Hui Li et al.
PLOS ONE (2013)
Irradiated Riboflavin Diminishes the Aggressiveness of Melanoma In Vitro and In Vivo
Daisy Machado et al.
PLOS ONE (2013)
Arsenic Trioxide Prevents Osteosarcoma Growth by Inhibition of GLI Transcription via DNA Damage Accumulation
Shunsuke Nakamura et al.
PLOS ONE (2013)
Decrease of miR-202-3p Expression, a Novel Tumor Suppressor, in Gastric Cancer
Yu Zhao et al.
PLOS ONE (2013)
Hedgehog Signaling Regulates Telomerase Reverse Transcriptase in Human Cancer Cells
Tapati Mazumdar et al.
PLOS ONE (2013)
RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling
Takashi Shimokawa et al.
RNA BIOLOGY (2013)
Arsenic trioxide inhibits viability of pancreatic cancer stem cells in culture and in a xenograft model via binding to SHH-Gli
Jin-bin Han et al.
ONCOTARGETS AND THERAPY (2013)
Genistein decreases the breast cancer stem-like cell population through Hedgehog pathway
Panhong Fan et al.
STEM CELL RESEARCH & THERAPY (2013)
A Patient With a Mild Holoprosencephaly Spectrum Phenotype and Heterotaxy and a 1.3 Mb Deletion Encompassing GLI2
Sietske H. G. Kevelam et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2012)
Hedgehog pathway regulators influence cervical cancer cell proliferation, survival and migration
Ivana Samarzija et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Regulation of murine normal and stress-induced erythropoiesis by Desert Hedgehog
Ching-in Lau et al.
BLOOD (2012)
Expression of microRNAs in basal cell carcinoma
M. Sand et al.
BRITISH JOURNAL OF DERMATOLOGY (2012)
The Crosstalk of mTOR/S6K1 and Hedgehog Pathways
Yan Wang et al.
CANCER CELL (2012)
Hedgehog Signaling Is a Novel Therapeutic Target in Tamoxifen-Resistant Breast Cancer Aberrantly Activated by PI3K/AKT Pathway
Bhuvaneswari Ramaswamy et al.
CANCER RESEARCH (2012)
Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2
Cuiping Yang et al.
CELL RESEARCH (2012)
Clinical findings in patients with GLI2 mutations - phenotypic variability
C. D. P. Bertolacini et al.
CLINICAL GENETICS (2012)
A Smoothened-Evc2 Complex Transduces the Hedgehog Signal at Primary Cilia
Karolin V. Dorn et al.
DEVELOPMENTAL CELL (2012)
Intricacies of hedgehog signaling pathways: A perspective in tumorigenesis
Swayamsiddha Kar et al.
EXPERIMENTAL CELL RESEARCH (2012)
Pericytoma with t(7;12) and ACTB-GLI1 fusion arising in bone
Julia A. Bridge et al.
HUMAN PATHOLOGY (2012)
A Polymeric Nanoparticle Encapsulated Small-Molecule Inhibitor of Hedgehog Signaling (NanoHHI) Bypasses Secondary Mutational Resistance to Smoothened Antagonists
Venugopal Chenna et al.
MOLECULAR CANCER THERAPEUTICS (2012)
Gli inhibitor GANT61 causes apoptosis in myeloid leukemia cells and acts in synergy with rapamycin
Deng Pan et al.
LEUKEMIA RESEARCH (2012)
Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells
X. Cao et al.
ONCOGENE (2012)
HEDGEHOG-GLI Signaling Drives Self-Renewal and Tumorigenicity of Human Melanoma-Initiating Cells
Roberta Santini et al.
STEM CELLS (2012)
Gli Proteins in Development and Disease
Chi-chung Hui et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 (2011)
Blocking Hedgehog Survival Signaling at the Level of the GLI Genes Induces DNA Damage and Extensive Cell Death in Human Colon Carcinoma Cells
Tapati Mazumdar et al.
CANCER RESEARCH (2011)
Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors
Patricia M. LoRusso et al.
CLINICAL CANCER RESEARCH (2011)
Promoter methylation in the PTCH gene in cervical epithelial cancer and ovarian cancer tissue as studied by eight novel Pyrosequencing® assays
Zarah M. Lef-Ohlin et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2011)
Dual Phosphorylation of Suppressor of Fused (Sufu) by PKA and GSK3β Regulates Its Stability and Localization in the Primary Cilium
Yan Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway
Elspeth M. Beauchamp et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
GLI1 facilitates the migration and invasion of pancreatic cancer cells through MUC5AC-mediated attenuation of E-cadherin
S. Inaguma et al.
ONCOGENE (2011)
Hedgehog beyond medulloblastoma and basal cell carcinoma
Stephan Teglund et al.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2010)
Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors
Akil Merchant et al.
BLOOD (2010)
Non-consensus GLI binding sites in Hedgehog target gene regulation
Martina Winklmayr et al.
BMC MOLECULAR BIOLOGY (2010)
Non-redundant role for the transcription factor Gli1 at multiple stages of thymocyte development
Ekati Drakopoulou et al.
CELL CYCLE (2010)
Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors
Chengbing Wang et al.
DEVELOPMENT (2010)
Nanog, Gli, and p53: a new network of stemness in development and cancer
Sebastian Brandner
EMBO JOURNAL (2010)
A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes
Hanna Tukachinsky et al.
JOURNAL OF CELL BIOLOGY (2010)
Forskolin, a Hedgehog signal inhibitor, inhibits cell proliferation and induces apoptosis in pediatric tumor cell lines
Hiroaki Yamanaka et al.
MOLECULAR MEDICINE REPORTS (2010)
Inhibition of GLI, but not Smoothened, induces apoptosis in chronic lymphocytic leukemia cells
P. Desch et al.
ONCOGENE (2010)
Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector
Jynho Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Context-dependent Regulation of the GLI Code in Cancer by HEDGEHOG and Non-HEDGEHOG Signals
Barbara Stecca et al.
JOURNAL OF MOLECULAR CELL BIOLOGY (2010)
Computational Prediction and Experimental Verification of New MAP Kinase Docking Sites and Substrates Including Gli Transcription Factors
Thomas C. Whisenant et al.
PLOS COMPUTATIONAL BIOLOGY (2010)
Sonic hedgehog negatively regulates pre-TCR-induced differentiation by a Gli2-dependent mechanism
Nicola J. Rowbotham et al.
BLOOD (2009)
Epidermal Growth Factor Receptor Signaling Synergizes with Hedgehog/GLI in Oncogenic Transformation via Activation of the MEK/ERK/JUN Pathway
Harald Schnidar et al.
CANCER RESEARCH (2009)
A Novel Splice Variant of GLI1 That Promotes Glioblastoma Cell Migration and Invasion
Hui-Wen Lo et al.
CANCER RESEARCH (2009)
Hedgehog Target Genes: Mechanisms of Carcinogenesis Induced by Aberrant Hedgehog Signaling Activation
Y. Katoh et al.
CURRENT MOLECULAR MEDICINE (2009)
A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers
Barbara Stecca et al.
EMBO JOURNAL (2009)
Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion
Frederic Varnat et al.
EMBO MOLECULAR MEDICINE (2009)
GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
Olivier Nolan-Stevaux et al.
GENES & DEVELOPMENT (2009)
MicroRNA profiling in human medulloblastoma
Elisabetta Ferretti et al.
INTERNATIONAL JOURNAL OF CANCER (2009)
Protein Kinase Cδ Negatively Regulates Hedgehog Signaling by Inhibition of Gli1 Activity
Qingsong Cai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
GLI1 Is a Direct Transcriptional Target of EWS-FLI1 Oncoprotein
Elspeth Beauchamp et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
The Gli3 Transcription Factor Expressed in the Thymus Stroma Controls Thymocyte Negative Selection Via Hedgehog-Dependent and -Independent Mechanisms
Ariadne L. Hager-Theodorides et al.
JOURNAL OF IMMUNOLOGY (2009)
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma
Paul A. Northcott et al.
NATURE GENETICS (2009)
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade
Joel M. Hyman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Deletion of Atoh1 Disrupts Sonic Hedgehog Signaling in the Developing Cerebellum and Prevents Medulloblastoma
Adriano Flora et al.
SCIENCE (2009)
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
Suzie J. Scales et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2009)
Biological determinants of endocrine resistance in breast cancer
Elizabeth A. Musgrove et al.
NATURE REVIEWS CANCER (2009)
Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells
Elisabetta Ferretti et al.
EMBO JOURNAL (2008)
Novel human glioma-associated oncogene 1 (GLI1) splice variants reveal distinct mechanisms in the terminal transduction of the hedgehog signal
Takashi Shimokawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
A paracrine requirement for hedgehog signalling in cancer
Robert L. Yauch et al.
NATURE (2008)
The Greig cephalopolysyndactyly syndrome
Leslie G Biesecker
Orphanet Journal of Rare Diseases (2008)
Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2
Yoshinori Abe et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
Sian Jones et al.
SCIENCE (2008)
The genomic landscapes of human breast and colorectal cancers
Laura D. Wood et al.
SCIENCE (2007)
Patched1 regulates Hedgehog signaling at the primary cilium
Rajat Rohatgi et al.
SCIENCE (2007)
Induction of sonic hedgehog mediators by transforming growth factor-β:: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo
Sylviane Dennler et al.
CANCER RESEARCH (2007)
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
Matthias Lauth et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells
Zhenyu Ji et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation
Nicola J. Rowbotham et al.
BLOOD (2007)
Melanomas require HEDGEHOG-GLI signaling reaulated by interactions between GLI1 and the RAS-MEK/AKT pathways
Barbara Stecca et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Frequent requirement of hedgehog signaling in non-small cell lung carcinoma
Z. Yuan et al.
ONCOGENE (2007)
Gli2 and Gli3 play distinct roles in the dorsoventral patterning of the mouse hindbrain
Melanie Lebel et al.
DEVELOPMENTAL BIOLOGY (2007)
The Gli code: an information nexus regulating cell fate, stemness and cancer
Ariel Ruiz i Altaba et al.
TRENDS IN CELL BIOLOGY (2007)
GLI2 mutations in four Brazilian patients:: How wide is the phenotypic spectrum?
Fedik Rahimov et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2006)
The consensus coding sequences of human breast and colorectal cancers
Tobias Sjoeblom et al.
SCIENCE (2006)
Multisite protein kinase A and glycogen synthase kinase 3β phosphorylation leads to Gli3 ubiquitination by SCFβTrCP
Denis Tempe et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer
Shibani Mukherjee et al.
CANCER BIOLOGY & THERAPY (2006)
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation
Y Pan et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Hemizygosity for chromosome 2q14.2-q22.1 spanning the GLI2 and PROC genes associated with growth hormone deficiency, polydactyly, deep vein thrombosis and urogenital abnormalities
P Gustavsson et al.
CLINICAL GENETICS (2006)
A potential role of alternative splicing in the regulation of the transcriptional activity of human GLI2 in gonadal tissues
M Speek et al.
BMC MOLECULAR BIOLOGY (2006)
Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling
NA Riobó et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Dual degradation signals control Gli protein stability and tumor formation
EG Huntzicker et al.
GENES & DEVELOPMENT (2006)
Evidence for the direct involvement of βTrCP in Gli3 protein processing
BW Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Hedgehog signaling is activated in subsets of esophageal cancers
XL Ma et al.
INTERNATIONAL JOURNAL OF CANCER (2006)
Holoprosencephaly: Clinical, anatomic, and molecular dimensions
M. Michael Cohen
BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY (2006)
The transcription factor Gli3 regulates differentiation of fetal CD4-CD8- double-negative thymocytes
AL Hager-Theodorides et al.
BLOOD (2005)
Cilia and Hedgehog responsiveness in the mouse
D Huangfu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2
E Roessler et al.
HUMAN MOLECULAR GENETICS (2005)
Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma
AM Snijders et al.
ONCOGENE (2005)
High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization
TL Naylor et al.
BREAST CANCER RESEARCH (2005)
The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins
M Paces-Fessy et al.
BIOCHEMICAL JOURNAL (2004)
Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1
RLH Bigelow et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Inhibition of prostate cancer proliferation by interference with SONICHEDGEHOG-GLI1 signaling
P Sanchez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Molecular genetic characterization of the genomic ACTB-GLI fusion in pericytoma with t(7;12)
A Dahlén et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Hedgehog signaling promotes prostate xenograft tumor growth
L Fan et al.
ENDOCRINOLOGY (2004)
Hedgehog signalling in colorectal tumour cells: Induction of apoptosis with cyclopamine treatment
D Qualtrough et al.
INTERNATIONAL JOURNAL OF CANCER (2004)
Hedgehog signalling in prostate regeneration, neoplasia and metastasis
SS Karhadkar et al.
NATURE (2004)
Loss-of-function mutations in the human GL12 gene are associated with pituitary anomalies and holoprosencephaly-like features
E Roessler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
DM Berman et al.
NATURE (2003)
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
SP Thayer et al.
NATURE (2003)
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
DN Watkins et al.
NATURE (2003)
Hedgehog regulates cell growth and proliferation by inducing cyclin D and cyclin E
M Duman-Scheel et al.
NATURE (2002)
Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex
SY Cheng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Hedgehog signaling in animal development: paradigms and principles
PW Ingham et al.
GENES & DEVELOPMENT (2001)
The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors
R Pola et al.
NATURE MEDICINE (2001)
Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation
G Bhardwaj et al.
NATURE IMMUNOLOGY (2001)
Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte
SV Outram et al.
IMMUNITY (2000)
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
BL Wang et al.
CELL (2000)
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