Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/ijms19082199
Keywords
infliximab; adalimumab; etanercept; certolizumab pegol; golimumab; hepatitis B virus; hepatitis C virus; drug-induced liver injury; non-alcoholic fatty liver disease; alcoholic hepatitis; autoimmune hepatitis
Funding
- Crohn's and Colitis Foundation of America
- Societa Italiana di Medicina Interna Premio di Ricerca
Ask authors/readers for more resources
Anti-tumor necrosis factor (TNF)-alpha agents represent an effective treatment for chronic inflammatory diseases. However, some concerns about their potentially undesirable effects on liver function have been reported. On the other hand, evidence of their therapeutic effects on certain liver diseases is accumulating. Many data showed the safety of anti-TNF-alpha in patients with chronic hepatitis B and C and in liver transplanted patients even if a strict follow-up and prophylaxis are recommended in well-defined subgroups. On the other side, anti-TNF-alpha-induced liver injury is not a rare event. However, it is often reversible after anti-TNF-alpha withdrawal. Anti-TNF-alpha agents have been tested in advanced stages of severe alcoholic hepatitis and non-alcoholic fatty liver disease. Limited data on the efficacy of anti-TNF-alpha in patients with autoimmune hepatitis and primary biliary cholangitis are also available. In this review, we explored the hepatic safety concerns in patients receiving anti-TNF-alpha agents with and without pre-existent hepatic diseases. In addition, the available evidence on their potential benefits in the treatment of specific hepatic diseases is discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available