Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 15, Issue 5, Pages 8713-8742Publisher
MDPI
DOI: 10.3390/ijms15058713
Keywords
NAFLD; NASH; mitochondria; liver; steatosis; fatty acid oxidation; PGC-1 alpha; sirtuin-1 (SIRT1); sirtuin-3 (SIRT3)
Funding
- Raymond E. and Vaona H. Peck Chair in Research
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Nonalcoholic fatty liver disease (NAFLD) affects about 30% of the general population in the United States and includes a spectrum of disease that includes simple steatosis, non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. Significant insight has been gained into our understanding of the pathogenesis of NALFD; however the key metabolic aberrations underlying lipid accumulation in hepatocytes and the progression of NAFLD remain to be elucidated. Accumulating and emerging evidence indicate that hepatic mitochondria play a critical role in the development and pathogenesis of steatosis and NAFLD. Here, we review studies that document a link between the pathogenesis of NAFLD and hepatic mitochondrial dysfunction with particular focus on new insights into the role of impaired fatty acid oxidation, the transcription factor peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha), and sirtuins in development and progression of NAFLD.
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