Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 16, Issue 1, Pages 193-217Publisher
MDPI AG
DOI: 10.3390/ijms16010193
Keywords
oxidative stress; neurodegenerative diseases; cancer; lipid peroxidation; oxysterol; carbonyl proteins; protein damage; DNA damage; stem cells
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [25293149]
- Thailand Research Fund [TRG5680039]
- Grants-in-Aid for Scientific Research [25670313, 24390172] Funding Source: KAKEN
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Reactive oxygen and nitrogen species have been implicated in diverse pathophysiological conditions, including inflammation, neurodegenerative diseases and cancer. Accumulating evidence indicates that oxidative damage to biomolecules including lipids, proteins and DNA, contributes to these diseases. Previous studies suggest roles of lipid peroxidation and oxysterols in the development of neurodegenerative diseases and inflammation-related cancer. Our recent studies identifying and characterizing carbonylated proteins reveal oxidative damage to heat shock proteins in neurodegenerative disease models and inflammation-related cancer, suggesting dysfunction in their antioxidative properties. In neurodegenerative diseases, DNA damage may not only play a role in the induction of apoptosis, but also may inhibit cellular division via telomere shortening. Immunohistochemical analyses showed co-localization of oxidative/ nitrative DNA lesions and stemness markers in the cells of inflammation-related cancers. Here, we review oxidative stress and its significant roles in neurodegenerative diseases and cancer.
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