Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 15, Issue 2, Pages 2840-2857Publisher
MDPI AG
DOI: 10.3390/ijms15022840
Keywords
flagella; Gram-negative; glycosylation
Funding
- Plan Nacional de I + D + i (Ministerio de Educacion, Ciencia y Deporte and Ministerio de Sanidad, Spain)
- Generalitat de Catalunya (Centre de Referencia en Biotecnologia)
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Protein glycosylation had been considered as an eccentricity of a few bacteria. However, through advances in analytical methods and genome sequencing, it is now established that bacteria possess both N-linked and O-linked glycosylation pathways. Both glycosylation pathways can modify multiple proteins, flagellins from Archaea and Eubacteria being one of these. Flagella O-glycosylation has been demonstrated in many polar flagellins from Gram-negative bacteria and in only the Gram-positive genera Clostridium and Listeria. Furthermore, O-glycosylation has also been demonstrated in a limited number of lateral flagellins. In this work, we revised the current advances in flagellar glycosylation from Gram-negative bacteria, focusing on the structural diversity of glycans, the O-linked pathway and the biological function of flagella glycosylation.
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