Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 15, Issue 3, Pages 4714-4732Publisher
MDPI
DOI: 10.3390/ijms15034714
Keywords
bioactive ceramic; nanostructure; pore architecture; preparation technique; bone repair
Funding
- Natural Science Foundation of China [51222506, 81372366]
- Hunan Provincial Natural Science Foundation of China [14JJ1006]
- Program for New Century Excellent Talents in University [NCET-12-0544]
- Fundamental Research Funds for the Central Universities [2011JQ005, 2012QNZT015]
- Fok Ying-Tong Education Foundation, China [131050]
- Shenzhen Strategic Emerging Industrial Development Funds [JCYJ20130401160614372]
- Central South University [2013JSJJ011, 2013JSJJ046]
- Hunan Provincial Innovation Foundation For Postgraduate
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Bioactive ceramics have received great attention in the past decades owing to their success in stimulating cell proliferation, differentiation and bone tissue regeneration. They can react and form chemical bonds with cells and tissues in human body. This paper provides a comprehensive review of the application of bioactive ceramics for bone repair and regeneration. The review systematically summarizes the types and characters of bioactive ceramics, the fabrication methods for nanostructure and hierarchically porous structure, typical toughness methods for ceramic scaffold and corresponding mechanisms such as fiber toughness, whisker toughness and particle toughness. Moreover, greater insights into the mechanisms of interaction between ceramics and cells are provided, as well as the development of ceramic-based composite materials. The development and challenges of bioactive ceramics are also discussed from the perspective of bone repair and regeneration.
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