4.7 Review

From Plasminogen to Plasmin: Role of Plasminogen Receptors in Human Cancer

Journal

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 15, Issue 11, Pages 21229-21252

Publisher

MDPI AG
DOI: 10.3390/ijms151121229

Keywords

actin; annexin 2; cytokeratin-8; enolase-1; plasmin; plasminogen; plasminogen receptor

Funding

  1. Excellence Cluster Cardiopulmonary System (ECCPS)
  2. German Center for Pulmonary Research (DZL: Deutsches Zentrum fur Lungenforschung)
  3. [SFB/TR84]

Ask authors/readers for more resources

Cell surface-associated proteolysis mediated by plasmin (PLA) is an essential feature of wound healing, angiogenesis and cell invasion, processes that are dysregulated in cancer development, progression and systemic spread. The generation of PLA, initiated by the binding of its precursor plasminogen (PLG) to the cell surface, is regulated by an array of activators, inhibitors and receptors. In this review, we will highlight the importance of the best-characterized components of the PLG/PLA cascade in the pathogenesis of cancer focusing on the role of the cell surface-PLG receptors (PLG-R). PLG-R overexpression has been associated with poor prognosis of cancer patients and resistance to chemotherapy. We will also discuss recent findings on the molecular mechanisms regulating cell surface expression and distribution of PLG-R.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available