Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 15, Issue 11, Pages 21229-21252Publisher
MDPI AG
DOI: 10.3390/ijms151121229
Keywords
actin; annexin 2; cytokeratin-8; enolase-1; plasmin; plasminogen; plasminogen receptor
Funding
- Excellence Cluster Cardiopulmonary System (ECCPS)
- German Center for Pulmonary Research (DZL: Deutsches Zentrum fur Lungenforschung)
- [SFB/TR84]
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Cell surface-associated proteolysis mediated by plasmin (PLA) is an essential feature of wound healing, angiogenesis and cell invasion, processes that are dysregulated in cancer development, progression and systemic spread. The generation of PLA, initiated by the binding of its precursor plasminogen (PLG) to the cell surface, is regulated by an array of activators, inhibitors and receptors. In this review, we will highlight the importance of the best-characterized components of the PLG/PLA cascade in the pathogenesis of cancer focusing on the role of the cell surface-PLG receptors (PLG-R). PLG-R overexpression has been associated with poor prognosis of cancer patients and resistance to chemotherapy. We will also discuss recent findings on the molecular mechanisms regulating cell surface expression and distribution of PLG-R.
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