Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 15, Issue 4, Pages 5263-5276Publisher
MDPI
DOI: 10.3390/ijms15045263
Keywords
magnesium; rare earth elements; corrosion; surface coating; biocompatibility
Funding
- National Institute of Health [SC2NS082475]
- NSF Engineering Research Center-Revolutionizing Metallic Biomaterials
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Magnesium (Mg) alloys are promising scaffolds for the next generation of cardiovascular stents because of their better biocompatibility and biodegradation compared to traditional metals. However, insufficient mechanical strength and high degradation rate are still the two main limitations for Mg materials. Hydrofluoric acid (HF) treatment and collagen coating were used in this research to improve the endothelialization of two rare earth-based Mg alloys. Results demonstrated that a nanoporous film structure of fluoride with thickness of similar to 20 mu m was formed on the Mg material surface, which improved the corrosion resistance. Primary human coronary artery endothelial cells (HCAECs) had much better attachment, spreading, growth and proliferation (the process of endothelialization) on HF-treated Mg materials compared to bare-or collagen-coated ones.
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