Related references
Note: Only part of the references are listed.Preclinical evaluation of IL2-based immunocytokines supports their use in combination with dacarbazine, paclitaxel and TNF-based immunotherapy
Francesca Pretto et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2014)
Sustained stimulation and expansion of Tregs by IL2 control autoimmunity without impairing immune responses to infection, vaccination and cancer
Guillaume Churlaud et al.
CLINICAL IMMUNOLOGY (2014)
Renegade homeostatic cytokine responses in T1 D: Drivers of regulatory/effector T cell imbalance
Shipra Gupta et al.
CLINICAL IMMUNOLOGY (2014)
Patients with the most advanced rheumatoid arthritis remain with Th1 systemic defects after TNF inhibitors treatment despite clinical improvement
Agata Kosmaczewska et al.
RHEUMATOLOGY INTERNATIONAL (2014)
Peripheral blood Th17/Treg imbalance in patients with low-active systemic lupus erythematosus896
Magdalena Szmyrka-Kaczmarek et al.
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ (2014)
Limitations of IL-2 and Rapamycin in Immunotherapy of Type 1 Diabetes
Audrey Baeyens et al.
DIABETES (2013)
β-Cell-Specific IL-2 Therapy Increases Islet Foxp3+Treg and Suppresses Type 1 Diabetes in NOD Mice
Mark C. Johnson et al.
DIABETES (2013)
Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy
Wei Liao et al.
IMMUNITY (2013)
Multiple Autoimmune-Associated Variants Confer Decreased IL-2R Signaling in CD4+CD25hi T Cells of Type 1 Diabetic and Multiple Sclerosis Patients
Karen Cerosaletti et al.
PLOS ONE (2013)
IL-2 Immunotherapy Reveals Potential for Innate Beta Cell Regeneration in the Non-Obese Diabetic Mouse Model of Autoimmune Diabetes
Yaiza Diaz-de-Durana et al.
PLOS ONE (2013)
Intersection between genetic polymorphisms and immune deviation in type 1 diabetes
Alice Long et al.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2013)
Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial
Agnes Hartemann et al.
LANCET DIABETES & ENDOCRINOLOGY (2013)
Type 1 diabetes: translating mechanistic observations into effective clinical outcomes
Kevan C. Herold et al.
NATURE REVIEWS IMMUNOLOGY (2013)
Cytokine Therapy With Interleukin-2/Anti-Interleukin-2 Monoclonal Antibody Complexes Expands CD4+CD25+Foxp3+ Regulatory T Cells and Attenuates Development and Progression of Atherosclerosis
Tam Nguyen Dinh et al.
CIRCULATION (2012)
Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs Yet Transiently Impairs β-cell Function
S. Alice Long et al.
DIABETES (2012)
STAT5 is a potent negative regulator of TFH cell differentiation
Robert J. Johnston et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Type 1 Diabetes-Associated IL2RA Variation Lowers IL-2 Signaling and Contributes to Diminished CD4+CD25+ Regulatory T Cell Function
Garima Garg et al.
JOURNAL OF IMMUNOLOGY (2012)
Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity
Shi-Bing Yang et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2012)
Elevated Th17 cells are accompanied by FoxP3+Treg cells decrease in patients with lupus nephritis
Qian Xing et al.
RHEUMATOLOGY INTERNATIONAL (2012)
Follicular Helper CD4 T Cells (T-FH)
Shane Crotty
ANNUAL REVIEW OF IMMUNOLOGY, VOL 29 (2011)
IL-2 production by dendritic cells promotes Foxp3+ regulatory T-cell expansion in autoimmune-resistant NOD congenic mice
Evridiki Sgouroudis et al.
AUTOIMMUNITY (2011)
Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4+CD25+Foxp3+ regulatory T cells
Ho-Jin Shin et al.
BLOOD (2011)
Beta cell function during rapamycin monotherapy in long-term type 1 diabetes
L. Piemonti et al.
DIABETOLOGIA (2011)
Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62LloFoxP3+ CD4+ T cells with limited suppressor activity
Kevin S. Goudy et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2011)
An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4+ T cells
S. A. Long et al.
GENES AND IMMUNITY (2011)
Inducible Adeno-Associated Virus-Mediated IL-2 Gene Therapy Prevents Autoimmune Diabetes
Kevin S. Goudy et al.
JOURNAL OF IMMUNOLOGY (2011)
CD4+FOXP3+ T Regulatory Cells in Human Autoimmunity: More Than a Numbers Game
S. Alice Long et al.
JOURNAL OF IMMUNOLOGY (2011)
Regulatory T-Cell Responses to Low-Dose Interleukin-2 in HCV-Induced Vasculitis
David Saadoun et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease
John Koreth et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
gp100 Peptide Vaccine and Interleukin-2 in Patients with Advanced Melanoma
Douglas J. Schwartzentruber et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies
Tom L. Van Belle et al.
PHYSIOLOGICAL REVIEWS (2011)
Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+ CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects
S. Alice Long et al.
DIABETES (2010)
Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity
Thomas R. Malek et al.
IMMUNITY (2010)
IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells
Yenkel Grinberg-Bleyer et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Cutting Edge: Increased IL-17-Secreting T Cells in Children with New-Onset Type 1 Diabetes
Ashish K. Marwaha et al.
JOURNAL OF IMMUNOLOGY (2010)
Cytokines and Regulatory T Cells in Rheumatoid Arthritis and Their Relationship with Response to Corticosteroids
Banesa de Paz et al.
JOURNAL OF RHEUMATOLOGY (2010)
Interleukin 10 and Tumor Necrosis Factor-α Genotypes in Rheumatoid Arthritis - Association with Clinical Response to Glucocorticoids
Banesa de Paz et al.
JOURNAL OF RHEUMATOLOGY (2010)
Genetics, pathogenesis and clinical interventions in type 1 diabetes
Jeffrey A. Bluestone et al.
NATURE (2010)
Regulatory T cells exert checks and balances on self tolerance and autoimmunity
Kajsa Wing et al.
NATURE IMMUNOLOGY (2010)
Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases
Jane Hoyt Buckner
NATURE REVIEWS IMMUNOLOGY (2010)
A glucocorticoid amplifies IL-2-induced selective expansion of CD4(+)CD25(+)FOXP3(+) regulatory T cells in vivo and suppresses graft-versus-host disease after allogeneic lymphocyte transplantation
Yanhui Xie et al.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2009)
Th17 and Natural Treg Cell Population Dynamics in Systemic Lupus Erythematosus
Ji Yang et al.
ARTHRITIS AND RHEUMATISM (2009)
Rapamycin Prevents and Breaks the Anti-CD3-Induced Tolerance in NOD Mice
Andrea Valle et al.
DIABETES (2009)
The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment
Di Yu et al.
IMMUNITY (2009)
Control of Regulatory T Cell Lineage Commitment and Maintenance
Steven Z. Josefowicz et al.
IMMUNITY (2009)
In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression
Kylie E. Webster et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
Follicular helper T cells are required for systemic autoimmunity
Michelle A. Linterman et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
The Initial Phase of an Immune Response Functions to Activate Regulatory T Cells
William E. O'Gorman et al.
JOURNAL OF IMMUNOLOGY (2009)
Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource
Calliope A. Dendrou et al.
NATURE GENETICS (2009)
Interleukin-2 Therapy in Patients with HIV Infection
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Apoptosis of CD4+CD25high T Cells in Type 1 Diabetes May Be Partially Mediated by IL-2 Deprivation
Parthav Jailwala et al.
PLOS ONE (2009)
Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation
Robert J. Johnston et al.
SCIENCE (2009)
Bcl6 Mediates the Development of T Follicular Helper Cells
Roza I. Nurieva et al.
SCIENCE (2009)
Correlation of clinical and virologic responses to antiviral treatment and regulatory T cell evolution in patients with hepatitis C virus-induced mixed cryoglobulinemia vasculitis
Dan-Avi Landau et al.
ARTHRITIS AND RHEUMATISM (2008)
Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-Cells
Paolo Monti et al.
DIABETES (2008)
A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study
Hakon Hakonarson et al.
DIABETES (2008)
Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: Roles of IL-2 versus IL-15
Cui-Hong Yang et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2008)
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
Qizhi Tang et al.
IMMUNITY (2008)
STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells
Laura Passerini et al.
INTERNATIONAL IMMUNOLOGY (2008)
The IL-2/CD25 Pathway Determines Susceptibility to T1D in Humans and NOD Mice
Calliope A. Dendrou et al.
JOURNAL OF CLINICAL IMMUNOLOGY (2008)
Impact of Protective IL-2 Allelic Variants on CD4+Foxp3+ Regulatory T Cell Function In Situ and Resistance to Autoimmune Diabetes in NOD Mice
Evridiki Sgouroudis et al.
JOURNAL OF IMMUNOLOGY (2008)
Suppression of Murine Allergic Airway Disease by IL-2:Anti-IL-2 Monoclonal Antibody-Induced Regulatory T Cells
Mark S. Wilson et al.
JOURNAL OF IMMUNOLOGY (2008)
Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts
Maria Koulmanda et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Phase I trial of BAY 50-4798, an interleukin-2-specific agonist in advanced melanoma and renal cancer
Kim Margolin et al.
CLINICAL CANCER RESEARCH (2007)
Cytokines and T-cell homeostasis
Onur Boyman et al.
CURRENT OPINION IN IMMUNOLOGY (2007)
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
Arian Laurence et al.
IMMUNITY (2007)
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
Jun Yamanouchi et al.
NATURE GENETICS (2007)
IL-2 is essential for TGF-β to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells
Song Guo Zheng et al.
JOURNAL OF IMMUNOLOGY (2007)
IL-2 receptor β-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells
Matthew A. Burchill et al.
JOURNAL OF IMMUNOLOGY (2007)
IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity
Hans D. Ochs et al.
IMMUNOLOGIC RESEARCH (2007)
IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo
Emmanuel Zorn et al.
BLOOD (2006)
Glucocorticoid amplifies IL-2-dependent expansion of functional FoxP3+CD4+CD25+ T regulatory cells in vivo and enhances their capacity to suppress EAE
Xin Chen et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2006)
IL-2 administration increases CD4+CD25hi Foxp3+ regulatory T cells in cancer patients
M Ahmadzadeh et al.
BLOOD (2006)
Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+ CD25+ regulatory T cells
H Zhang et al.
NATURE MEDICINE (2005)
A function for interleukin 2 in Foxp3-expressing regulatory T cells
JD Fontenot et al.
NATURE IMMUNOLOGY (2005)
Functional defects and the influence of age on the frequency of CD4+CD25+ T-Cells in type 1 diabetes
TM Brusko et al.
DIABETES (2005)
mRNA quantification of T-bet, GATA-3, IFN-γ, and IL-4 shows a defective Th1 immune response in the peripheral blood from rheumatoid arthritis patients:: Link with disease activity
M Kawashima et al.
JOURNAL OF CLINICAL IMMUNOLOGY (2005)
Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
R Setoguchi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Differential response of murine CD4+CD25+ and CD4+CD25- T cells to dexamethasone-induced cell death
X Chen et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2004)
Naturally arising CD4(+) regulatory T cells for immunologic self-tolerance and negative control of immune responses
S Sakaguchi
ANNUAL REVIEW OF IMMUNOLOGY (2004)
CD4+CD25+ regulatory T-cell deficiency in patients with hepatitis C-mixed cryoglobulinemia vasculitis
O Boyer et al.
BLOOD (2004)
Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice
A Rabinovitch et al.
DIABETES (2002)
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
ME Brunkow et al.
NATURE GENETICS (2001)
Share Paper
