Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 15, Issue 11, Pages 20045-20053Publisher
MDPI
DOI: 10.3390/ijms151120045
Keywords
sponge; Scalarispongia; sesterterpenoid; scalarane; cytotoxicity
Funding
- Korea Institute of Ocean Science and Technology
- Ministry of Oceans and Fisheries of Korea
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Eight scalarane sesterterpenoids, including four new compounds, were isolated from the marine sponge Scalarispongia sp. The structures of the new compounds were elucidated by 2D-NMR and HRMS analyses. All of the isolated compounds, with the exception of 16-O-deacetyl-12,16-epi-scalarolbutanolide, showed significant in vitro cytotoxicity (GI50 values down to 5.2 mu M) against six human cancer cell lines.
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